An ophthalmologic fluoroquinolone antibiotic; active against Gram-negative and Gram-positive aerobic and anaerobic bacterial strains (MICs = 0.006-1.56 μg/ml); inhibits LPS-stimulated production of the inflammatory cytokines IL-1β

Besifloxacin (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
405165-61-9
Storage:
4
UN-No:
Non-Hazardous - /

Besifloxacin is an ophthalmologic fluoroquinolone antibiotic that is active against Gram-negative and Gram-positive aerobic and anaerobic bacterial strains (MICs = 0.006-1.56 μg/ml).{38427} It inhibits LPS-stimulated production of the inflammatory cytokines IL-1β, IL-8, IL-6, and IL-1α in human THP-1 monocytes.{38428} Besifloxacin, when 2 drops of a 0.6% solution are applied per eye, yields a concentration of 2 μg/g which is greater than the MIC90s of ophthalmologic isolates of H. influenzae, S. pneumoniae, S. aureus, and Corynebacterium and reduces the number of bacteria found in the aqueous, but not vitreous, humor in a rabbit model of bacterial endophthalmitis.{38427,38429}  

 

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SKU: 23692 - 10 mg Category:

Description

An ophthalmologic fluoroquinolone antibiotic; active against Gram-negative and Gram-positive aerobic and anaerobic bacterial strains (MICs = 0.006-1.56 μg/ml); inhibits LPS-stimulated production of the inflammatory cytokines IL-1β, IL-8, IL-6, and IL-1α in human THP-1 monocytes; reduces the number of bacteria found in the aqueous, but not vitreous, humor in a rabbit model of bacterial endopthalmitis when administered topically using 2 drops of a 0.6% solution per eye,

Formal name: 7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride

Synonyms:  BOL-303224-A

Molecular weight: 430.3

CAS: 405165-61-9

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Neuroscience|Ophthalmology

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