A naturally occurring furanocoumarin; inhibits migration and invasion of HT-1080 fibrosarcoma cells at sub-cytotoxic concentrations via inhibition of MMP-9 expression; shows antiproliferative activity against HepG2 liver

Bergamottin – 1 mg

Brand:
Cayman
CAS:
7380-40-7
Storage:
-20
UN-No:
Non-Hazardous - /

Bergamottin is a furanocoumarin found in grapefruit juice and lemon, lime, and bergamot oils that has diverse biological activities.{41018} In vitro, bergamottin inhibits migration and invasion of HT-1080 fibrosarcoma cells at sub-cytotoxic concentrations via inhibition of matrix metalloproteinase-9 (MMP-9) expression.{41019} It shows antiproliferative activity against HepG2 liver, HL-60 leukemia, and BGC-823 gastric cancer cell lines in a dose-dependent manner and induces cell death of CHO cells following near ultraviolet irradiation.{41018,41020} Bergamottin inhibits the cytochrome P450 isoform 3A4 (CYP3A4; Ki = 7.7 μM) and is a mixed inhibitor of simvastatin (Item No. 10010344) drug metabolism (Ki = 174 μM).{41021,41022} It also increases glucose consumption in HepG2 cells in a dose-dependent manner.{41020}  

 

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SKU: 10009439 - 1 mg Category:

Description

A naturally occurring furanocoumarin; inhibits migration and invasion of HT-1080 fibrosarcoma cells at sub-cytotoxic concentrations via inhibition of MMP-9 expression; shows antiproliferative activity against HepG2 liver, HL-60 leukemia, and BGC-823 gastric cancer cell lines in a dose-dependent manner; induces cell death of CHO cells following near ultraviolet irradiation; inhibits CYP3A4 (Ki = 7.7 μM); a mixed inhibitor of simvastatin drug metabolism (Ki = 174 μM); increases glucose consumption in HepG2 cells in a dose-dependent manner

Formal name: 4-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one

Synonyms:  5-Geranoxypsoralen

Molecular weight: 338.4

CAS: 7380-40-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Metabolism||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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