A dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle; recognized as a non-selective channel blocker

Bepridil (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
68099-86-5
Storage:
-20
UN-No:
Non-Hazardous - /

Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle.{22485,28732} It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents.{31412} For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4) channels, sarcoplasmic ATP-sensitive K+ (KATP) channels, and Na+-activated (KNa) channels (IC50s = 7.1, 22, 9.4, 10, and 2.2 µM, respectively).{24593,31415,31413,28732} It also activates mitochondrial ATP-sensitive KATP channels (ED50 = 27.5 µM).{31414}  

 

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Description

A dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle; recognized as a non-selective channel blocker

Formal name: β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine, monohydrochloride

Synonyms: 

Molecular weight: 403

CAS: 68099-86-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Heart|Arrhythmia

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