A histamine H1 receptor antagonist; selective over H3

Bepotastine (besylate) – 5 mg

Brand:
Cayman
CAS:
190786-44-8
Storage:
4
UN-No:
Non-Hazardous - /

Bepotastine is an antagonist of the histamine H1 receptor that is selective over H3, α1-, α2-, and β-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors.{40405} It reduces dye leakage from the nasal passages of rats acutely sensitized to an antigen (ED50 = 0.03 mg/kg) and inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 µg/kg).{40408,40407} Bepotastine prevents conjunctival vascular hyperpermeability in a guinea pig model of conjunctivitis in a dose-dependent manner.{40406} Formulations containing bepotastine have been used in the treatment of itching associated with allergic conjunctivitis.  

 

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SKU: 23721 - 5 mg Category:

Description

A histamine H1 receptor antagonist; selective over H3, α1-, α2-, and β-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors; reduces dye leakage from the nasal passages of sensitized rats (ED50 = 0.03 mg/kg); inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 µg/kg); dose-dependently prevents conjunctival vascular hyperpermeability a in guinea pig model of conjunctivitis

Formal name: 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid, monobenzenesulfonate

Synonyms:  Bepotastine besilate|TAU-284

Molecular weight: 547.1

CAS: 190786-44-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Neuroscience|Ophthalmology

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