An inhibitor of mucin synthesis; inhibits glucosamine labeling in Caco-2

Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside – 250 mg

Brand:
Cayman
CAS:
3554-93-6
Storage:
-20
UN-No:
- /

Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside (benzyl-α-GalNAc) is an inhibitor of mucin synthesis.{54644,54645,54646} It inhibits glucosamine labeling, a marker of mucin synthesis, in Caco-2, HT-29, and T84 colon cancer cells when used at a concentration of 2 mM.{54644} Benzyl-α-GalNAc (0.4, 0.6, and 0.8 mg/ml) enhances cell death induced by 5-fluorouracil (Item No. 14416) in Capan-1 and HPAF-II cells.{54645} LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells.{54646}  

 

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SKU: 31747 - 250 mg Category:

Description

An inhibitor of mucin synthesis; inhibits glucosamine labeling in Caco-2, HT-29, and T84 colon cancer cells at 2 mM; enhances 5-fluorouracil-induced cell death in Capan-1 and HPAF-II cells at 0.4, 0.6, and 0.8 mg/ml; LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells

Formal name: phenylmethyl 2-(acetylamino)-2-deoxy-α-D-galactopyranoside

Synonyms:  Benzyl N-acetyl-α-D-galactosaminide|Benzyl-α-GalNAc

Molecular weight: 311.3

CAS: 3554-93-6

Purity: ≥98%

Formulation: A crystalline solid

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