A voltage-gated sodium channel blocker; blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV

Benzonatate – 5 mg

Brand:
Cayman
CAS:
104-31-4
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Benzonatate is a reversible voltage-gated sodium channel blocker.{37382} It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. In vivo, benzonatate (0.85 mg/min) reduces the frequency, but has no effect on the amplitude, of the cough reflex in anesthetized dogs.{37383} Formulations containing benzonatate have been used as antitussive agents for the treatment of coughs.  

 

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Description

A voltage-gated sodium channel blocker; blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively); blocks 80% of Nav1.3 currents in N1E-115 cells (100 μM); reduces the frequency of the cough reflex in anesthetized dogs

Formal name: 4-(butylamino)-benzoic acid, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester

Synonyms: 

Molecular weight: 603.8

CAS: 104-31-4

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience

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