An orally bioavailable antiprotozoal agent; inhibits the growth of the parasites T. cruzi

Benznidazole – 100 mg

Brand:
Cayman
CAS:
22994-85-0
Storage:
-20
UN-No:
Non-Hazardous - /

Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.  

 

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SKU: 29090 - 100 mg Category:

Description

An orally bioavailable antiprotozoal agent; inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively); inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions at 100 μM; decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease at 100 mg/kg per day

Formal name: 2-nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide

Synonyms:  NSC 299972|Ro 07-1051

Molecular weight: 260.3

CAS: 22994-85-0

Purity: ≥95%

Formulation: A crystalline solid

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