An ENaC blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles; an NCX blocker that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 ~ 100 nM); an inhibitor of TRPP3 (IC50 = 1.1 μM)

Benzamil (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
161804-20-2
Storage:
-20
UN-No:
Non-Hazardous - /

Benzamil is a derivative of amiloride (Item No. 14409).{48507} Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. It is also an inhibitor of the Na+/Ca2+ exchanger (NCX) that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 = ~100 nM).{48508} Benzamil inhibits transient receptor potential polycystin-L (TRPP3; IC50 = 1.1 μM), a member of the TRP superfamily of cation channels.{24798}  

 

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Description

An ENaC blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles; an NCX blocker that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 ~ 100 nM); an inhibitor of TRPP3 (IC50 = 1.1 μM)

Formal name: 3,5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide, monohydrochloride

Synonyms: 

Molecular weight: 356.2

CAS: 161804-20-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Neuroscience

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