A selective

Bentamapimod – 1 mg

Brand:
Cayman
CAS:
848344-36-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}  

 

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Description

A selective, orally bioavailable inhibitor of JNK1, JNK2, and JNK3 (IC50s = 80, 90, and 230 nM, respectively); induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis

Formal name: α-[2-[[4-(4-morpholinylmethyl)phenyl]methoxy]-4-pyrimidinyl]-2-benzothiazoleacetonitrile

Synonyms:  AS-602801

Molecular weight: 457.5

CAS: 848344-36-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JNK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cancer Stem Cell Research|Proliferation||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JNK Signaling||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity

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