A DNA alkylating agent; inhibits growth of SKW-3

Bendamustine (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
3543-75-7
Storage:
-20
UN-No:
- 2811 / 6.1

Bendamustine is a purine analog and DNA alkylating agent.{41416} It inhibits growth of SKW-3, Reh, CML-T1, BV-173, and HL-60 leukemia cell lines (IC50s = 27.0, 28.6, 15.6, 20.8, and 57.7 μM, respectively) but not MCF-7 and MDA-MB-231 breast cancer cell lines (IC50s = >200 and >200 μM, respectively).{41417} It kills B cell-chronic lymphocytic leukemia (B-CLL) cells derived from naïve and bendamustine-pretreated patients (LD50s = 6.8-8.3 and 3.8-4.9 mg/ml, respectively).{41418} Bendamustine (50 mg/kg) inhibits tumor growth by 9% and 96% alone and in combination with ofatumumab, respectively, in a JVM-3 CLL mouse xenograft model.{41419} It activates the DNA-damage stress response, the base excision DNA repair pathway, and apoptosis, as well as inhibits mitotic checkpoints and induces mitotic catastrophe.{41416} Formulations containing bendamustine have been used to treat CLL and non-Hodgkin lymphoma.  

 

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Description

A DNA alkylating agent; inhibits growth of SKW-3, Reh, CML-T1, BV-173, and HL-60 leukemia cell lines (IC50s = 27.0, 28.6, 15.6, 20.8, and 57.7 μM, respectively) but not MCF-7 and MDA-MB-231 breast cancer cell lines (IC50s = >200 and >200 μM, respectively); kills B-CLL cells derived from naïve and bendamustine-pretreated patients (LD50s= 6.8-8.3 and 3.8-4.9 mg/ml, respectively); inhibits tumor growth by 9% and 96% alone and in combination with ofatumumab, respectively, in a JVM-3 CLL mouse xenograft model (50 mg/kg)

Formal name: 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid, monohydrochloride

Synonyms:  SDX-105

Molecular weight: 394.7

CAS: 3543-75-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair

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