A prodrug of benazeprilat; inhibits enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM); decreases the triglyceride and total cholesterol levels in normotensive rats (30 mg/kg); decreases aortic atherosclerosis in cholesterol-fed rabbits (3 mg/kg per day); reduces blood pressure in spontaneously hypertensive rats (0.1-10 mg/kg per day); decreases proteinuria in cats with chronic kidney disease (0.5-1 mg/kg per day)

Benazepril (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
86541-74-4
Storage:
-20
UN-No:
Non-Hazardous - /

Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Item No. 21796).{38021} It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM).{26178} It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day.{41556} Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{41557} It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day.{41558} Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.  

 

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SKU: 23804 - 500 mg Category:

Description

A prodrug of benazeprilat; inhibits enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM); decreases the triglyceride and total cholesterol levels in normotensive rats (30 mg/kg); decreases aortic atherosclerosis in cholesterol-fed rabbits (3 mg/kg per day); reduces blood pressure in spontaneously hypertensive rats (0.1-10 mg/kg per day); decreases proteinuria in cats with chronic kidney disease (0.5-1 mg/kg per day)

Formal name: (3S)-3-[[1S-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid, monohydrochloride

Synonyms:  CGS 14824A

Molecular weight: 461

CAS: 86541-74-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease|Chronic Kidney Disease||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism

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