A cyclodepsipeptide inhibitor of lipid droplet formation; inhibits lipid droplet formation at 3 and 10 µM and inhibits cholesterol synthesis (IC50 = 0.41 µM) in primary mouse peritoneal macrophages; inhibits ACAT activity in mouse macrophage membranes (IC50 = 5.5 µM); reduces the size of aortic atherosclerotic lesions in Ldlr-/- and ApoE-/- mouse models of atherosclerosis at 25 and 50 mg/kg

Beauveriolide III – 500 µg

Brand:
Cayman
CAS:
221111-70-2
Storage:
-20
UN-No:
Non-Hazardous - /

Beauveriolide III is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.{57337} It inhibits lipid droplet formation when used at concentrations of 3 and 10 µM, as well as inhibits cholesterol synthesis (IC50 = 0.41 µM), in primary mouse peritoneal macrophages.{57337,11643} Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 5.5 µM).{11643} Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic atherosclerotic lesions in Ldlr-/- and ApoE-/- mouse models of atherosclerosis.  

 

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Description

A cyclodepsipeptide inhibitor of lipid droplet formation; inhibits lipid droplet formation at 3 and 10 µM and inhibits cholesterol synthesis (IC50 = 0.41 µM) in primary mouse peritoneal macrophages; inhibits ACAT activity in mouse macrophage membranes (IC50 = 5.5 µM); reduces the size of aortic atherosclerotic lesions in Ldlr-/- and ApoE-/- mouse models of atherosclerosis at 25 and 50 mg/kg

Formal name: cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl]

Synonyms: 

Molecular weight: 487.6

CAS: 221111-70-2

Purity: ≥95%

Formulation: A solid

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