An antagonist of σ1 receptors (Ki = 9 nM); selective for σ1 receptors over σ2 (Ki = 449 nM) and serotonin 5-HT2 receptors (Ki = 2

BD 1063 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
206996-13-6
Storage:
-20
UN-No:
Non-Hazardous - /

BD 1063 is an antagonist of sigma-1 (σ1) receptors (Ki = 9 nM).{39221} It is selective for σ1 receptors over σ2 (Ki = 449 nM) and serotonin 5-HT2 receptors (Ki = 2,552 nM), as well as opioid, dopamine D2, PCP, serotonin 5-HT1, α1-, α2-, and β-adrenergic receptors where it has Ki values of greater than 10 µM. BD 1063 (30 mg/kg) inhibits locomotor activity induced by cocaine (Item Nos. 16186 | ISO60176) in mice and decreases ethanol intake in a dose-dependent manner in two rat models of excessive drinking when administered at doses ranging from 3.3 to 11 mg/kg.{39221,37408}  

 

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Description

An antagonist of σ1 receptors (Ki = 9 nM); selective for σ1 receptors over σ2 (Ki = 449 nM) and serotonin 5-HT2 receptors (Ki = 2,552 nM); selective for σ1 receptors over opioid, dopamine D2, PCP, serotonin 5-HT1, α1-, α2-, and β-adrenergic receptors (Kis = >10 µM); inhibits locomotor activity induced by cocaine in mice (30 mg/kg); decreases ethanol intake in rat models of excessive drinking (3.3-11 mg/kg)

Formal name: 1-[2-(3,4-dichlorophenyl)ethyl]-4-methyl-piperazine, dihydrochloride

Synonyms: 

Molecular weight: 346.1

CAS: 206996-13-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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