A potent and selective PDE11 inhibitor (IC50 = 0.28 µM); increased cAMP levels

BC-11-38 – 10 mg

Brand:
Cayman
CAS:
686770-80-9
Storage:
-20
UN-No:
Non-Hazardous - /

BC-11-38 is a potent and selective phosphodiesterase (PDE) 11 inhibitor (IC50s = 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively).{33958} Gene association studies suggested that PDE11 was involved in adrenal function, and in H295R human adrenocortical cells, BC-11-38 increased cAMP and cortisol levels and activating transcription factor 1 (ATF-1) phosphorylation.{33959,33960,33958}  

 

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SKU: 20167 - Category:

Description

A potent and selective PDE11 inhibitor (IC50 = 0.28 µM); increased cAMP levels, ATF1 phosphorylation, and cortisol levels in human adrenocortical cells

Formal name: 6,7-dihydro-3-phenyl-2-(propylthio)-thieno[3,2-d]pyrimidin-4(3H)-one

Synonyms: 

Molecular weight: 304.4

CAS: 686770-80-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cancer|Cell Signaling|cAMP Signaling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids

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