The biological effects of PGD2 (Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors

BAY u3405 – 10 mg

Brand:
Cayman
CAS:
116649-85-5
Storage:
-20
UN-No:
Non-Hazardous - /

The biological effects of prostaglandin D2 (PGD2; Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2. BAY u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of the thromboxane receptor (TP receptor).{12335} BAY u3405 is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM.{11248} BAY u3405 is more potent at the DP2 receptor than the TP receptor by 4-5 fold. BAY u3405 is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.  

 

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SKU: 10156 - 10 mg Category:

Description

The biological effects of PGD2 (Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2. BAY u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of the TP receptor.{12335} BAY u3405 is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM.{11248} BAY u3405 is more potent at the DP2 receptor than the TP receptor by 4-5 fold. BAY u3405 is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.

Formal name: 3R-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid

Synonyms:  Ramatroban

Molecular weight: 416.5

CAS: 116649-85-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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