A cell-permeable

BAY 61-3606 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1615197-10-8
Storage:
-20
UN-No:
Non-Hazardous - /

BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki = 7.5 nM; IC50 = 10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk.{31575,23658,31574} BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells.{31575} At 3 mg/kg, oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema.{31575} It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9.{31573} This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma.{20382}  

 

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SKU: 11423 - 5 mg Category:

Description

A cell-permeable, reversible inhibitor of Syk (Ki = 7.5 nM; IC50 = 10 nM); inhibits degranulation (IC50 = 5-46 nM) and blocks cytokine release from mast cells; also sensitizes MCF-7 breast cancer cells to TRAIL-mediated apoptosis

Formal name: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide, monohydrochloride

Synonyms: 

Molecular weight: 426.9

CAS: 1615197-10-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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