A potent and selective BRD1 inhibitor (IC50 = 6 nM); also inhibits the second bromodomain of TAF1 (IC50 = 13 nM); >30-fold selective over BRPF1

BAY-299 – 10 mg

Brand:
Cayman
CAS:
2080306-23-4
Storage:
-20
UN-No:
Non-Hazardous - /

BAY-299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 (IC50 = 6 nM), also known as BRPF2, and the second bromodomain of transcription initiation factor TFIID subunits 1 (TAF1; IC50 = 13 nM).{33973} BAY-299 is >30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2 and is >300-fold selective over BRD4. See the Structural Genomics Consortium (SGC) website for more information.  

 

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SKU: 19777 - Category:

Description

A potent and selective BRD1 inhibitor (IC50 = 6 nM); also inhibits the second bromodomain of TAF1 (IC50 = 13 nM); >30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2; >300-fold selective over BRD4

Formal name: 2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3(2H)-dione

Synonyms: 

Molecular weight: 429.5

CAS: 2080306-23-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area

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