An orally bioavailable inhibitor of Mps1 (TTK; IC50 = 0.27 nM); inactivates the spindle assembly checkpoint

BAY 12-17389 – 5 mg

Brand:
Cayman
CAS:
1554458-53-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

BAY 12-17389 is an inhibitor of monopolar spindle 1 (Mps1 or TTK; IC50 = 0.27 nM), a serine/threonine/tyrosine kinase involved in cell division.{34467} It is orally bioavailable and, through its effects on Mps1, inactivates the spindle assembly checkpoint, accelerates mitosis, and causes chromosomal misalignment and missegregation.{34467} BAY 12-17389 induces cell death in Mps1-overexpressing cancer cells and improves efficacy of paclitaxel (Item No. 10461) in tumor therapy.{34467}  

 

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Description

An orally bioavailable inhibitor of Mps1 (TTK; IC50 = 0.27 nM); inactivates the spindle assembly checkpoint, accelerates mitosis, and causes chromosomal misalignment and missegregation

Formal name: N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-benzamide

Synonyms: 

Molecular weight: 561.5

CAS: 1554458-53-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Signaling

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