A Bax inhibitor; decreases Bax

Bax Inhibitor Peptide V5 – 10 mg

Brand:
Cayman
CAS:
579492-81-2
Storage:
-20
UN-No:
Non-Hazardous - /

Bax inhibitor peptide V5 is an inhibitor of Bax.{54043} It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-ĸB p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 µM.{54044} It inhibits apoptosis induced by etoposide (Item No. 12092) in Hep3B human hepatoma cells when used at a concentration of 200 µM.{54043} Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation.{54045} Bax inhibitor peptide V5, when used at a concentration of 100 µM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{54044}  

 

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SKU: 30243 - 10 mg Category:

Description

A Bax inhibitor; decreases Bax, Bad, and NF-ĸB p65 levels and increases XIAP and Bcl-2 levels in isolated mouse pancreatic islets at 100 µM; inhibits etoposide-induced apoptosis in Hep3B cells at 200 µM; decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation at 5 mg/ml; inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in an STZ-induced mouse model of diabetes when used at 100 µM in syngeneic pancreatic islet cells prior to transplantation

Formal name: L-valyl-L-prolyl-L-methionyl-L-leucyl-L-lysine

Synonyms:  BIP V5|VPMLK

Molecular weight: 586.8

CAS: 579492-81-2

Purity: ≥98%

Formulation: A solid

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