A VEGFR inhibitor (IC50s = 0.82

BAW 2881 – 10 mg

Brand:
Cayman
CAS:
861875-60-7
Storage:
-20
UN-No:
Non-Hazardous - /

BAW 2881 is a vascular endothelial growth factor receptor (VEGFR) inhibitor (IC50s = 0.82, 0.037, and 0.42 µM for hVEGFR1, 2, and 3, respectively).{31717} It inhibits Tie2 and RET with IC50 values of 0.65 and 0.41 µM, respectively, but demonstrates IC50 values great than 10 µM toward a large panel of additional kinases.{31717} BAW 2881 was shown to block VEGF-A-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells and lymphatic endothelial cells in vitro.{31717} In a mouse model of psoriasis, both oral and topical administration of BAW 2881 reduced psoriasis-like inflammation in ear skin.{31717} Topical application of BAW 2881 also reduced VEGF-A-induced vascular permeability and inhibited contact hypersensitivity reactions and UV-B-induced erythema in the skin of domestic pigs.{31717}  

 

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Description

A VEGFR inhibitor (IC50s = 0.82, 0.037, and 0.42 µM for hVEGFR1, 2, and 3, respectively); also inhibits Tie2 and RET with IC50 values of 0.65 and 0.41, respectively; reduces inflammation in a mouse model of psoriasis and in pig models of contact hypersensitivity and UV-B-induced erythema

Formal name: 6-[(2-amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide

Synonyms:  NVP-BAW 2881

Molecular weight: 424.4

CAS: 861875-60-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Immunology & Inflammation|Autoimmunity

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