A cyclodepsipeptide insecticide; synthesized by B. bassiana and V. lecanii; induces atony in B. mori when given orally at concentrations as low as 4 ppm; inhibits the muscarinic

Bassianolide – 500 µg

Brand:
Cayman
CAS:
64763-82-2
Storage:
-20
UN-No:
Non-Hazardous - /

Bassianolide is a cyclodepsipeptide insecticide synthesized by the fungal species B. bassiana and V. lecanii.{34745, 34746} In vivo, the oral administration of bassianolide induces atony in the silkworm B. mori at a concentration of 4 ppm and is lethal at doses exceeding 8 ppm. Atony is similarly induced in silkworm larvae at oral doses as low as 2 µg/larva.{34745} In isolated guinea pig smooth muscle tissue, bassianolide (0.01-1 µM) specifically inhibits the muscarinic, but not nicotinic, receptor-induced contractions in response to acetylcholine.{34747, 34748}  

 

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Description

A cyclodepsipeptide insecticide; synthesized by B. bassiana and V. lecanii; induces atony in B. mori when given orally at concentrations as low as 4 ppm; inhibits the muscarinic, but not nicotinic, receptor-induced contractions in response to acetylcholine in smooth muscle

Formal name: Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-leucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-leucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-leucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-leucyl]

Synonyms:  (-)-Bassianolide|NSC 321804

Molecular weight: 909.2

CAS: 64763-82-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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