A dual agonist of GP-BAR1 and FXR (EC50s = 0.2 and 1 μM

BAR502 – 5 mg

Brand:
Cayman
CAS:
1612191-86-2
Storage:
-20
UN-No:
Non-Hazardous - /

BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR; EC50s = 0.2 and 1 μM, respectively).{38107} It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter α (OSTα), and small heterodimer partner (SHP) in primary hepatocytes isolated from FXR wild-type mice. BAR502 also increases cAMP-luciferase reporter gene expression, a marker of GP-BAR1 activity, in HEK293T cells.  

 

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Description

A dual agonist of GP-BAR1 and FXR (EC50s = 0.2 and 1 μM, respectively); increases the expression of FXR-regulated BSEP, OSTα, and SHP in primary hepatocytes isolated from FXR wild-type mice; increases cAMP-luciferase reporter gene expression in HEK293T cells,

Formal name: (3α,5β,6α,7α)-6-ethyl-24-norcholane-3,7,23-triol

Synonyms: 

Molecular weight: 392.6

CAS: 1612191-86-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs

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