Description
A flavonoid; inhibits human recombinant PDE5A1 (IC50 = 0.16 μM) in a cell-free assay; protects PC12 rat adrenal cells from hydrogen peroxide-induced death at 25 μM; inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively); decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a STZ-induced rat model of neurodegeneration at 10 mg/kg per day; increases ICP in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction at 10 mg/kg per day,
Formal name: 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Synonyms: Icariin II|Icariside II
Molecular weight: 514.5
CAS: 113558-15-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders||Research Area|Neuroscience|Neuroprotection
