A prodrug form of 5-ASA; cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA; decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane

Balsalazide – 5 mg

Brand:
Cayman
CAS:
80573-04-2
Storage:
-20
UN-No:
Non-Hazardous - /

Balsalazide is a prodrug form of 5-aminosalicylic acid (5-ASA; Item No. 70265).{48536} It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB).{48537} Formulations containing balsalazide have been used in the treatment of ulcerative colitis.  

 

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Description

A prodrug form of 5-ASA; cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA; decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of DNCB-induced colitis at 600 mg/kg per day

Formal name: 5-[(1E)-2-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]diazenyl]-2-hydroxy-benzoic acid

Synonyms: 

Molecular weight: 357.3

CAS: 80573-04-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis

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