A fluoroquinolone antibiotic; active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro

Balofloxacin – 5 g

Brand:
Cayman
CAS:
127294-70-6
Storage:
-20
UN-No:
Non-Hazardous - /

Balofloxacin is a fluoroquinolone antibiotic.{36836} It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro, including K. pneumoniae, H. influenzae, N. gonorrhoeae, P. mirabilis, S. pyogenes, and methicillin-resistant S. aureus (MRSA; MIC50s = 0.025-0.78 μg/ml). Balofloxacin inhibits DNA gyrase from E. coli, P. aeruginosa, and S. aureus (IC50s = 0.47, 11, and 2.5 μg/ml, respectively, in a DNA supercoiling assay). It reduces mortality in mouse models of systemic S. aureus, MRSA, S. pneumoniae, K. pneumoniae, and P. aeruginosa infection (ED50s = 5, 20, 10, 160, and 50.4 mg/kg, respectively).{36837}  

 

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SKU: 25504 - 5 g Category:

Description

A fluoroquinolone antibiotic; active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro, including K. pneumoniae, H. influenzae, N. gonorrhoeae, P. mirabilis, S. pyogenes, and MRSA (MIC50s = 0.025-0.78 μg/ml); inhibits DNA gyrase from E. coli, P. aeruginosa, and S. aureus (IC50s = 0.47, 11.0, and 2.5 μg/ml, respectively, in a DNA supercoiling assay); reduces mortality in mouse models of systemic S. aureus, MRSA, S. pneumoniae, K. pneumoniae, and P. aeruginosa infection (ED50s = 5, 20, 10, 160, and 50.4 mg/kg, respectively)

Formal name: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-3-quinolinecarboxylic acid

Synonyms:  Q-35

Molecular weight: 389.4

CAS: 127294-70-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|STDs

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