A selective

Bafilomycin B1 – 5 mg

Brand:
Cayman
CAS:
88899-56-3
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring. They inhibit the growth of Gram-positive bacteria and fungi.{20718} Bafilomycin B1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range.{20718} It is at least 1,000-fold less potent at most other types of ATPases.{20718} When used at 100 nM, the related macrolide bafilomycin A1 blocks V-ATPase-mediated acidification of lysosomes during autophagy, preventing protein degradation.{20721} Remarkably, at only 1 nM, both bafilomycin A1 or B1 dramatically attenuate chloroquine-induced apoptosis of neurons without altering autophagy.{20720}  

 

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Description

A selective, reversible inhibitor of V-ATPases in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range; at 100 nM, the related bafilomycin A1 blocks V-ATPase-mediated acidification of lysosomes during autophagy, preventing protein degradation

Formal name: 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-2E-butenoic acid, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl ester

Synonyms:  Setamycin

Molecular weight: 816

CAS: 88899-56-3

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Macrolides||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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