PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.{6619

BADGE – 25 g

Brand:
Cayman
CAS:
1675-54-3
Storage:
22
UN-No:
Non-Hazardous - /

PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.{6619,2160,6620,4136} Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-Δ12,14-prostaglandin J2, and NSAIDS.{8461,7575,1424,4044} BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPARγ.{8241} BADGE binds to PPARγ with an apparent Kd of 100 µM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.{8241}  

 

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SKU: 70790 - 25 g Category:

Description

PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.{6619,2160,6620,4136} Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-.DELTA.12,14-PGJ2, and NSAIDS.{8461,7575,1424,4044} BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPARγ.{8241} BADGE binds to PPARγ with an apparent Kd of 100 µM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.{8241}

Formal name: 2,2′-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane

Synonyms:  Bisphenol A diglycidyl ether

Molecular weight: 340.4

CAS: 1675-54-3

Purity: ≥85%

Formulation: A neat oil

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