An inhibitor of B-RAF and C-RAF (IC50s = 24 and 25 nM

B-RAF IN 1 – 25 mg

Brand:
Cayman
CAS:
950736-05-7
Storage:
-20
UN-No:
Non-Hazardous - /

B-RAF IN 1 is an inhibitor of B-RAF (IC50 = 24 nM) that also inhibits C-RAF (IC50 = 25 nM).{41136} It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα, at concentrations greater than 2 µM, but does inhibit p38α and CAMKII (IC50s = 216 and 822 nM, respectively). B-RAF IN 1 binds to B-RAF in the inactive conformation based on co-crystallization with the wild-type enzyme. It inhibits proliferation of WM 266-4 and HT29 cells with IC50 values of 920 and 780 nM, respectively.  

 

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SKU: 23434 - 25 mg Category:

Description

An inhibitor of B-RAF and C-RAF (IC50s = 24 and 25 nM, respectively); selective over 13 other kinases at concentrations greater than 2 µM; inhibits p38α and CAMKII (IC50s = 216 and 822 nM, respectively); inhibits proliferation WM 266-4 and HT29 cells (IC50s = 920 and 780 nM, respectively)

Formal name: N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)-benzamide

Synonyms:  B-RAF Inhibitor 1

Molecular weight: 515.5

CAS: 950736-05-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|p38 MAPK Signaling

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