Description
A synthetic β-lactam antibiotic of the monobactam class; active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all); interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all); increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg)
Formal name: 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl-propanoic acid
Synonyms: SQ 26,776
Molecular weight: 435.4
CAS: 78110-38-0
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics|Monobactams||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia
