A prodrug form of azilsartan; reduces blood pressure and decreases PAI-1 levels in the plasma

Azilsartan Medoxomil – 10 mg

Brand:
Cayman
CAS:
863031-21-4
Storage:
-20
UN-No:
Non-Hazardous - /

Azilsartan medoxomil is a prodrug form of azilsartan (Item No. 26091), a potent and selective angiotensin II receptor 1 (AT1) antagonist.{36288,36289} Azilsartan medoxomil (0.1-10 mg/kg) reduces blood pressure and decreases plasminogen activator inhibitor 1 (PAI-1) levels in the plasma, left ventricle, and aortic wall in mice in a dose-dependent manner.{36289} It also inhibits the pressor response induced by angiotensin II (Item No. 17150) in normotensive rats (ID50 = 0.12 mg/kg) and reduces blood pressure and improves glucose infusion, a marker of insulin sensitivity, in spontaneously hypertensive rats.{36290} Azilsartan medoxomil also has more potent antiproteinuric effects in Wistar fatty rats than olmesartan medoxomil (Item No. 11614). Formulations containing azilsartan medoxomil have been used in the treatment of hypertension.  

 

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SKU: 23805 - 10 mg Category:

Description

A prodrug form of azilsartan; reduces blood pressure and decreases PAI-1 levels in the plasma, left ventricle, and aortic wall in mice in a dose-dependent manner when administered at doses ranging from 0.1-10 mg/kg; inhibits the angiotensin II-induced pressor response in normotensive rats (ID50 = 0.12 mg/kg); reduces blood pressure and improves glucose infusion in spontaneously hypertensive rats; has more potent antiproteinuric effects in Wistar fatty rats than olmesartan medoxomil

Formal name: 1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

Synonyms:  TAK-491

Molecular weight: 568.5

CAS: 863031-21-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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