An inverse agonist of AT1; the active metabolite of azilsartan medoxomil; reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9)

Azilsartan – 1 g

Brand:
Cayman
CAS:
147403-03-0
Storage:
-20
UN-No:
Non-Hazardous - /

Azilsartan is an inverse agonist of the angiotensin II type 1 receptor (AT1; IC50 = 2.6 nM) and the active metabolite of the prodrug azilsartan medoxomil (Item No. 23805).{46062} It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9), an effect that persists following washout, indicating slow dissociation.  

 

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SKU: 26091 - 1 g Category:

Description

An inverse agonist of AT1; the active metabolite of azilsartan medoxomil; reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9)

Formal name: 1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid

Synonyms:  TAK-536

Molecular weight: 456.5

CAS: 147403-03-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Cardiovascular System|Vasculature|Vasodilation

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