azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.{14080}

azido-FTY720 – 1 mg

Brand:
Cayman
CAS:
881914-35-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).{11284} Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.{11738} azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.{14080}  

 

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SKU: 10008612 - 1 mg Category:

Description

azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.{14080}

Formal name: 2-amino-2-[2-(4-(1-azido-2-octylphenyl))ethyl]-1,3-propanediol

Synonyms: 

Molecular weight: 348.5

CAS: 881914-35-8

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Labeling & Detection||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sphingolipids

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