A negative allosteric modulator of mGluR5 receptors (IC50 = 7.6 nM in a FLIPR calcium mobilization assay); selective for mGluR5 over mGluR1-4

AZD 9272 – 10 mg

Brand:
Cayman
CAS:
327056-26-8
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 9272 is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5; IC50 = 7.6 nM in a FLIPR calcium mobilization assay).{45717} It is selective for mGluR5 over mGluR1-4 and 6-8 in a FLIPR calcium mobilization assay (IC50s = >30 µM) and a panel of 134 receptors, ion channels, nuclear hormone receptors, transporters, and enzymes at 10 µM in radioligand binding assays.  

 

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SKU: 29717 - 10 mg Category:

Description

A negative allosteric modulator of mGluR5 receptors (IC50 = 7.6 nM in a FLIPR calcium mobilization assay); selective for mGluR5 over mGluR1-4, and 6-8 in a FLIPR calcium mobilization assay (IC50s = >30 µM) and a panel of 134 receptors, ion channels, nuclear hormone receptors, transporters, and enzymes at 10 µM in radioligand binding assays

Formal name: 3-fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile

Synonyms: 

Molecular weight: 284.2

CAS: 327056-26-8

Purity: ≥98%

Formulation: A solid

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