A reversible inhibitor of ErbB1/EGFR

AZD 8931 – 10 mg

Brand:
Cayman
CAS:
848942-61-0
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 8931 is a reversible inhibitor of the receptor tyrosine kinases ErbB1/EGFR, ErbB2/HER2, and ErbB3/HER3 (IC50s = 4, 3, and 4 nM, respectively, for autophosphorylation).{42033} In vitro, AZD 8931 (0.01, 0.1, and 1 µM) suppresses cell growth and induces apoptosis in SUM149 and FC-IBC-02 human breast cancer cell lines.{42034} In vivo, AZD 8931 (6.25-50 mg/kg) inhibits tumor growth in BT474c, Calu-3, LoVo, FaDu, and PC-9 mouse xenograft models.{42033} When administered in combination with paclitaxel (Item No. 10461), AZD 8931 inhibits inflammatory breast cancer tumor growth in a mouse xenograft model when administered at a dose of 25 mg/kg per day.{42034}  

 

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SKU: 24196 - 10 mg Category:

Description

A reversible inhibitor of ErbB1/EGFR, ErbB2/HER2, and ErbB3/HER3 (IC50s = 4, 3, and 4 nM, respectively, for autophosphorylation); suppresses cell growth and induces apoptosis in SUM149 and FC-IBC-02 human breast cancer cell lines at 0.01, 0.1, and 1 µM; inhibits tumor growth in BT474c, Calu-3, LoVo, FaDu, and PC-9 mouse xenograft models from 6.25-50 mg/kg; inhibits inflammatory breast cancer tumor growth in a mouse xenograft model when administered in combination with paclitaxel at 25 mg/kg per day

Formal name: 4-[[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl-1-piperidineacetamide

Synonyms:  Sapitinib

Molecular weight: 473.9

CAS: 848942-61-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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