An inhibitor of PI3Kα and PI3Kδ (IC50s = 6.2 and 5.7 nM

AZD 8835 – 1 mg

Brand:
Cayman
CAS:
1620576-64-8
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 8835 is an inhibitor of PI3Kα and PI3Kδ (IC50s = 6.2 and 5.7 nM, respectively).{48678} It is selective for PI3Kα and PI3Kδ over PI3Kβ and PI3Kγ (IC50s = 431 and 90 nM, respectively). AZD 8835 inhibits Akt phosphorylation in PIK3CA constitutively active mutant BT474 cells and Jeko-1 B cells that express endogenous PI3Kδ (IC50s = 57 and 49 nM, respectively). In vivo, AZD 8835 (25 mg/kg) reduces tumor growth and Akt phosphorylation in a SKOV3 mouse xenograft model. It also increases the activity of CD8+ effector T cells and reduces tumor growth in a C26 mouse syngeneic tumor model.{48679}  

 

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SKU: 29166 - 1 mg Category:

Description

An inhibitor of PI3Kα and PI3Kδ (IC50s = 6.2 and 5.7 nM, respectively); selective for PI3Kα and PI3Kδ over PI3Kβ and PI3Kγ (IC50s = 431 and 90 nM, respectively); inhibits Akt phosphorylation in PIK3CA constitutively active mutant BT474 cells and Jeko-1 B cells that express endogenous PI3Kδ (IC50s = 57 and 49 nM, respectively); reduces tumor growth and Akt phosphorylation in an SKOV3 mouse xenograft model at 25 mg/kg; increases the activity of CD8+ effector T cells and reduces tumor growth in a C26 mouse syngeneic tumor model

Formal name: 1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-3-hydroxy-1-propanone

Synonyms: 

Molecular weight: 469.5

CAS: 1620576-64-8

Purity: ≥98%

Formulation: A crystalline solid

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