An inhibitor of DNA-PK (IC50 = 0.63 nM in an enzyme assay); selective for DNA-PK over TTK (IC50 = 5.012 μM)

AZD 7648 – 10 mg

Brand:
Cayman
CAS:
2230820-11-6
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK; IC50 = 0.63 nM in an enzyme assay).{48616} It is selective for DNA-PK over TTK (IC50 = 5.012 μM), as well as JAK1, JAK2, JAK3, Aurora A, and Aurora B (IC50s = >10 μM for all). AZD 7648 reduces tumor growth in a FaDu ATM KO pharynx cancer mouse xenograft model when administered at doses of 37.5 or 75 mg/kg twice per day and induces tumor regression at these doses when administered in combination with the PARP inhibitor olaparib (Item No. 10621).  

 

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SKU: 28598 - 10 mg Category:

Description

An inhibitor of DNA-PK (IC50 = 0.63 nM in an enzyme assay); selective for DNA-PK over TTK (IC50 = 5.012 μM), as well as JAK1, JAK2, JAK3, Aurora A, and Aurora B (IC50s = >10 μM for all); reduces tumor growth in a FaDu ATM KO pharynx cancer mouse xenograft model at 37.5 or 75 mg/kg twice per day and induces tumor regression at these doses when administered in combination with the PARP inhibitor olaparib

Formal name: 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one

Synonyms: 

Molecular weight: 380.4

CAS: 2230820-11-6

Purity: ≥98%

Formulation: A crystalline solid

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