A selective ATR inhibitor (IC50 = 1 nM); inhibits the proliferation of various solid and hematological cell lines either as monotherapy or when used in combination with DNA damaging chemotherapy agents or ionizing radiation

AZD 6738 – 5 mg

Brand:
Cayman
CAS:
1352226-88-0
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 6738 is an orally bioavailable inhibitor of the serine/threonine protein kinase ataxia telangiectasia mutated (ATM) and Rad3-related (ATR; IC50 = 1 nM).{32892} It can inhibit ATR substrate Chk1 Ser345 phosphorylation in cells with an IC50 value of 74 nM.{32892} AZD 6738 has been shown to inhibit the proliferation of various solid and hematological cell lines with IC50 values of less than 1 µM and to reduce tumor growth in several ATM-deficient xenograft models.{32892} When used in combination with either DNA damaging chemotherapy agents or ionizing radiation, AZD 6738 demonstrated synergistic cell killing activity across multiple cell lines in vitro and in xenograft studies.{32892}  

 

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Description

A selective ATR inhibitor (IC50 = 1 nM); inhibits the proliferation of various solid and hematological cell lines either as monotherapy or when used in combination with DNA damaging chemotherapy agents or ionizing radiation

Formal name: 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine

Synonyms: 

Molecular weight: 412.5

CAS: 1352226-88-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ATM Signaling

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