A bivalent BRD4 inhibitor (IC50 = 5 nM) that simultaneously binds two bromodomains in BRD4; demonstrates antitumor activity in multiple xenograft models of acute myeloid leukemia

AZD 5153 – 10 mg

Brand:
Cayman
CAS:
1869912-39-9
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 5153 an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM).{32416} It can simultaneously bind two bromodomains in BRD4, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma.{32416}  

 

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Description

A bivalent BRD4 inhibitor (IC50 = 5 nM) that simultaneously binds two bromodomains in BRD4; demonstrates antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma

Formal name: (3R)-4-[2-[4-[1-(3-methoxy-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy]ethyl]-1,3-dimethyl-2-piperazinone

Synonyms: 

Molecular weight: 479.6

CAS: 1869912-39-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains

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