A CXCR2 antagonist (IC50 = 0.79 nM in a radioligand binding assay); inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1

AZD 5069 – 5 mg

Brand:
Cayman
CAS:
878385-84-3
Storage:
-20
UN-No:
- /

AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay).{45374} It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.  

 

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Description

A CXCR2 antagonist (IC50 = 0.79 nM in a radioligand binding assay); inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively); inhibits BALF neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation at 3 and 10 μmol/kg

Formal name: N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-1-azetidinesulfonamide

Synonyms: 

Molecular weight: 476.5

CAS: 878385-84-3

Purity: ≥98%

Formulation: A crystalline solid

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