An adenosine A2 receptor antagonist (Ki = 1.7 nM for the human receptor); inhibits adenosine-induced cAMP production in CHO cells expressing the human A2 receptor (IC50 = 0.79 μM); reverses NECA-induced suppression of IFN-γ secretion in CD8+ T cells; reduces tumor growth when administered alone and in combination with checkpoint inhibitors in syngeneic mouse tumor models

AZD 4635 – 10 mg

Brand:
Cayman
CAS:
1321514-06-0
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 4635 is an adenosine A2 receptor antagonist (Ki = 1.7 nM for the human receptor).{47334} It inhibits adenosine-induced cAMP production in CHO cells expressing the human A2 receptor (IC50 = 0.79 μM) and reverses suppression of IFN-γ secretion induced by 5′-N-ethylcarboxamidoadenosine (NECA; Item No. 21420) in CD8+ T cells. AZD 4635 reduces tumor growth when administered alone and in combination with checkpoint inhibitors in syngeneic mouse tumor models.  

 

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SKU: 26322 - 10 mg Category:

Description

An adenosine A2 receptor antagonist (Ki = 1.7 nM for the human receptor); inhibits adenosine-induced cAMP production in CHO cells expressing the human A2 receptor (IC50 = 0.79 μM); reverses NECA-induced suppression of IFN-γ secretion in CD8+ T cells; reduces tumor growth when administered alone and in combination with checkpoint inhibitors in syngeneic mouse tumor models

Formal name: 6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine

Synonyms:  HTL-1071

Molecular weight: 315.7

CAS: 1321514-06-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer

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