A selective inhibitor of MCT1 (Ki = 1.6 nM)

AZD 3965 – 1 mg

Brand:
Cayman
CAS:
1448671-31-5
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 3965 is a potent inhibitor of monocarboxylate transporter 1 (MCT1; Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport.{32004} It displays six-fold selectivity for MCT1 over MCT2 and is without effect against MCT4 at 10 µM. AZD 3965 increases intratumor lactate levels and decreases tumor growth in mice bearing COR-L103 small cell lung cancer (SCLC) xenografts.{32004} AZD 3965 also enhances radiosensitivity in mice with SCLC xenografts.{32003}  

 

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SKU: 19912 - Category:

Description

A selective inhibitor of MCT1 (Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport; increases intratumor lactate levels and decreases tumor growth in mice bearing SCLC xenografts

Formal name: 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Synonyms: 

Molecular weight: 515.5

CAS: 1448671-31-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Metabolism

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