Description
An inhibitor of c-Kit-driven cell proliferation; selectively inhibits growth of c-Kit mutant (GI50s = 1-971 nM) and PDGFR mutant (GI50s = 1-22 nM) Ba/F3 cell lines over Ba/F3 cell lines expressing Tel-KDR/VEGFR2 (GI50 = 1,378 nM); induces tumor regression in a Ba/F3 mouse xenograft model at 20 mg/kg per day; induces tumor regression in a mouse allograft model using Ba/F3 cells expressing KIT-exon 11 del/V654A at 20 mg/kg twice per day
Formal name: N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-1H-1,2,3-triazole-1-acetamide
Synonyms:
Molecular weight: 479.5
CAS: 2248003-60-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling
