A dual mTORC1/mTORC2 inhibitor (IC50s = 40.7 and 5.75 nM

AZD 3147 – 500 µg

Brand:
Cayman
CAS:
1101810-02-9
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 3147 is an orally bioavailable dual inhibitor of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2 (IC50s = 40.7 and 5.75 nM, respectively, in MDA-MB-468 cells).{55175} It is selective for mTOR over PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ (IC50s = 1.51, 912, 5,495, 9,333, and 6,310 nM, respectively, in enzyme assays).  

 

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Description

A dual mTORC1/mTORC2 inhibitor (IC50s = 40.7 and 5.75 nM, respectively, in MDA-MB-468 cells); selective for mTOR over PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ (IC50s = 1.51, 912, 5,495, 9,333, and 6,310 nM, respectively, in enzyme assays)

Formal name: N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N’-(2-hydroxyethyl)-thiourea

Synonyms: 

Molecular weight: 517.7

CAS: 1101810-02-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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