An antagonist of the P2Y12 receptor (IC50 = 25 nM); selectively binds to the P2Y12 receptor (Kd = 11 nM) over more than 100 enzymes

AZD 1283 – 25 mg

Brand:
Cayman
CAS:
919351-41-0
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 1283 is an antagonist of the purinergic P2Y12 receptor (IC50 = 25 nM in a GTPγS assay in CHO cells).{52053} It selectively binds to the P2Y12 receptor (Kd = 11 nM) over more than 100 enzymes, receptors, and ion channels, including the P2Y1, platelet activating factor (PAF), and thromboxane A2 receptors, at 10 µM.{52053},{52054} AZD 1283 increases blood flow and inhibits platelet aggregation induced by ADP in a modified Folts dog model of thrombosis with ED50 values of 3 and 10 µg/kg per minute, respectively.  

 

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SKU: 27649 - 25 mg Category:

Description

An antagonist of the P2Y12 receptor (IC50 = 25 nM); selectively binds to the P2Y12 receptor (Kd = 11 nM) over more than 100 enzymes, receptors, and ion channels, including the P2Y1, PAF, and thromboxane A2 receptors at 10 µM; increases blood flow and inhibits ADP-induced platelet aggregation in a modified Folts dog model of thrombosis (ED50s = 3 and 10 µg/kg per minute, respectively)

Formal name: 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylic acid, ethyl ester

Synonyms:  6-[4-[[(Benzylsulfonyl)amino]carbonyl]piperidin-1-yl]-5-cyano-2-methylnicotinic acid ethyl ester|AZD 1283

Molecular weight: 470.5

CAS: 919351-41-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Vasculature

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