A potent

AZD 1208 – 25 mg

Brand:
Cayman
CAS:
1204144-28-4
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively).{32021} It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16 xenograft tumors in mice.{32021} It has efficacy against acute myeloid leukemia and glioblastoma cells when combined with mTOR and p110α inhibitors, respectively.{32019,32020}  

 

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Description

A potent, selective, and orally available inhibitor of Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively); causes cell cycle arrest and apoptosis in MOLM-16 cells and inhibits the growth of MOLM-16 xenograft tumors in mice

Formal name: (5Z)-[[2-[(3R)-3-amino-1-piperidinyl][1,1′-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione

Synonyms: 

Molecular weight: 379.5

CAS: 1204144-28-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PIMs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PIM Signaling

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