A highly selective inhibitor of Aurora kinase B (IC50 = 0.37 nM); inhibits the proliferation of hematopoietic malignant cells (IC50s = 3-40 nM) and tumor xenograft growth in vivo

AZD 1152-HQPA – 5 mg

Brand:
Cayman
CAS:
722544-51-6
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 1152-HQPA is an inhibitor of Aurora kinase B (IC50 = 0.37 nM) that demonstrates ~3,700-fold greater selectivity for Aurora kinase B over Aurora kinase A (IC50 = 1.368 µM).{31459,31461} It does not have activity against a panel of 50 other serine-threonine or tyrosine kinases, including FLT3, JAK2, and Abl.{31459,31461} AZD 1152-HQPA has been shown to inhibit the proliferation of hematopoietic malignant cells (IC50s = 3-40 nM), disrupting spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis, and to inhibit tumor xenograft growth in vivo.{31461,31460}  

 

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SKU: 11602 - 5 mg Category:

Description

A highly selective inhibitor of Aurora kinase B (IC50 = 0.37 nM); inhibits the proliferation of hematopoietic malignant cells (IC50s = 3-40 nM) and tumor xenograft growth in vivo

Formal name: 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide

Synonyms:  Barasertib-HQPA

Molecular weight: 507.6

CAS: 722544-51-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Aurora Signaling

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