A tumor-inhibiting antibiotic that inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis

Azaserine – 10 mg

Brand:
Cayman
CAS:
115-02-6
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces that functions as a glutamine analog.{23660,21899} At 25 μM, it inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase and glucosamine-6-phosphate isomerase.{21899,18311} Azaserine also inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins.{23661} Azaserine has been shown to protect against hyperglycemic endothelial damage through its antioxidant effects.{23661}  

 

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Description

A tumor-inhibiting antibiotic that inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, N-formylglycineamidine ribotide synthetase and glucosamine-6-phosphate isomerase; also inhibits the hexosamine biosynthetic pathway, which has been shown to protect against hyperglycemic endothelial damage

Formal name: O-(2-diazoacetyl)-L-serine

Synonyms:  CI-337|CN 15757|NSC 742|O-Diazoacetyl-L-serine

Molecular weight: 173.1

CAS: 115-02-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Metabolism||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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