A selective

Azamulin – 5 mg

Brand:
Cayman
CAS:
76530-44-4
Storage:
-20
UN-No:
Non-Hazardous - /

Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources).{30387} It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms.{30387} Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.{30387,30386}  

 

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Description

A selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources); potently blocks the hydroxylation of testosterone and midazolam by CYP3A4

Formal name: (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 2-[(3-amino-1H-1,2,4-triazol-5-yl)thio]-acetic acid

Synonyms:  Antibiotic TDM 85-530|SA 85530b

Molecular weight: 478.7

CAS: 76530-44-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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