Description
An azadirachtin with diverse biological activities; has antifeedant activity against P. xylostella third instar larvae at 3 mg/ml induces mortality (LC50 = 1.03 mg/ml); induces mortality in M. incognita second instar larvae (LD50 = 125.8 ppm); reduces the number of papillomas formed on mouse skin in a model of skin carcinogenesis induced by peroxynitrite and TPA at 780 nmol in the drinking water but is not cytotoxic to HL-60, A549, AZ521, SK-BR-3, or CRL1579 cancer cells (IC50s = >20 µM for all); It induces osteoblast differentiation and increases the rate of osteoblast proliferation in primary calvarial osteoblast cells at 100 pM and 10 nM but not 1 pM, 1 µM, or 100 µM
Formal name: (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-octahydro-3,8-dihydroxy-4-methyl-10-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-7H,8H-furo[3′,4′:4,4a]naphtho[1,8-bc]furan-5,10a(1H)-dicarboxylic acid, 5,10a-dimethyl ester
Synonyms: 3-Tigloylazadirachtol|Deacetylazadirachtinol
Molecular weight: 662.7
CAS: 106500-25-8
Purity: ≥95%
Formulation: A solid
