A CNS depressant; reduces transmission through the sympathetic ganglia

Azacyclonol – 50 g

Brand:
Cayman
CAS:
115-46-8
Storage:
-20
UN-No:
Non-Hazardous - /

Azacyclonol is a CNS depressant.{43955} It reduces transmission through the sympathetic ganglia, decreasing electrically stimulated contractile responses in feline nictitating membrane. It reduces coordinated locomotor activity in mice by greater than 50% when administered at doses of 71, 142, and 213 mg/kg.{43952} Azacyclonol (142 mg/kg) decreases hyperactivity induced by pipradol, D-amphetamine, morphine, and cocaine. It also increases the duration of sleeping time induced by hexobarbital. Azacyclonol is also a metabolite of the histamine H1 receptor antagonist terfenadine (Item No. 20305).{43953,43954} It is formed from terfenadine by the cytochrome P450 (CYP) isoform CYP3A4.{43954}  

 

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SKU: 27303 - 50 g Category:

Description

A CNS depressant; reduces transmission through the sympathetic ganglia, decreasing electrically stimulated contractile responses in feline nictitating membrane; reduces coordinated locomotor activity in mice by >50% in mice at 71, 142, and 213 mg/kg; decreases hyperactivity induced by pipradol, D-amphetamine, morphine, and cocaine; increases the duration of hexobarbital-induced sleeping time; a metabolite of terfenadine formed via CYP3A4

Formal name: α,α-diphenyl-4-piperidinemethanol

Synonyms:  MDL 4829|MER 17|γ-Pipradol

Molecular weight: 267.4

CAS: 115-46-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals||Research Area|Neuroscience|Behavioral Neuroscience

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